Study of Tumor Necrosis Factor-Alpha-Induced Protein 3 Gene Single-Nucleotide Variants in JAK2 V617F-Positive Myeloproliferative Disorders: A Case–Control Study

Background and Objectives: Myeloproliferative neoplasms (MPNs) are Philadelphia negative disorders involving polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF). Although JAK2 mutation is almost involved, other several mutations linked to MPNs risk prognosis. TNFAIP3 genetic related cancers autoimmune diseases. Our study aimed demonstrate the effects of rs2230926_T/G & rs5029939_C/G SNVs gene on prognosis V617F positive MPNs.
 Methods: Matched 2 groups in age, sex race were enrolled our research; 80 cases group 130 normal healthy controls with follow up for 3 years. Taqman assay probes involved real time polymerase chain reaction (PCR) utilized variants analysis.
 Results: The rs2230926 rs5029939 modest linkage disequilibrium (LD) cases. observed frequencies G allele its genotypes both more prevalent patients than controls. bleeding symptoms presence splenomegaly existent heterozygous genotype combined respectively. overall survival (OS) was lower containing but progression free (PFS) affected only SNV.
 Conclusion: revealed association increased incidence as well poor clinical course Egyptian ethnic.